Totte,
I can work for countless hours without any problem. 10 minutes FilterForge and my left mouse button stops responding. I also had it a few times just hanging on a filter slider. Killing the Filter Forge application at that point does not make any difference for my left mouse click. only a reboot will make it work again. I noticed that the problem stays away if I start Filter Forge from Photoshop. It only seems to occur with the stand alone application.

I'm using an one month old Wacom intus 4 L tablet in combination with the additional Wacom mouse. I also installed a month ago the latest drivers for this device. As told before the tablet works perfect with any other application on my MAC (Photoshop, Maya, 3d Coat.....).
Thanks for your reply.
Peter.